MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin. Five dosage strengths of MINIVELLE are available to provide nominal in vivo delivery rates of 0.025, 0.0375, 0.05, 0.075, or 0.1 mg of estradiol per day via the skin. Minivelle package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Minivelle is a brand-name estradiol transdermal patch used to treat moderate to severe menopause symptoms like hot flashes and night sweats. It's also prescribed to help prevent osteoporosis in postmenopausal women. Estrogen is necessary for many processes in the body. Minivellees are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Minivelle is also used to prevent postmenopausal osteoporosis, or to treat ovarian disorders. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin. MINIVELLE (estradiol transdermal system) contains estradiol in a multipolymeric adhesive. The system is designed to release estradiol continuously upon application to intact skin. Minivelle is a transdermal patch that contains estradiol (an estrogen hormone) and is used to reduce hot flashes after menopause and postmenopausal osteoporosis. Minivelle (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, caused by menopause. It can also prevent bone loss (osteoporosis) after menopause. It's a type of hormone replacement therapy. For US Audience Only. Estradiol Transdermal System is a prescription medicine patch that contains estradiol (an estrogen hormone). Estradiol Transdermal System is used to reduce moderate to severe hot flashes due to menopause and to help prevent postmenopausal osteoporosis (thin weak bones).